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KMID : 0379520140300010049
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한국독성학회지
2014 Volume.30 No. 1 p.49 ~ p.54
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Hepatoprotective Effect of Aged Black Garlic Extract in Rodents
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Shin Jung-Hyu
Lee Chang-Woo
Oh Soo-Jin
Yun Ji-Eun
Kang Moo-Rim
Han Sang-Bae
Park Heung-sik
Jung Jae-Chul
Chung Yoon-Hoo
Kang Jong-Soon
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Abstract
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In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.
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KEYWORD
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Aged black garlic, Liver injury, Carbon tetrachloride, D-galactosamine, Non-alcoholic fatty liver disease
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